Table 2 IC50 values of the examined substances against HCT116 and MCF7 cell lines.

From: Synthesis and in silico studies of certain benzo[f]quinoline-based heterocycles as antitumor agents

Compds

In vitro Cytotoxicity IC50 (µM)a

HCT116

MCF7

Doxorubicin

5.23 ± 0.3

4.17 ± 0.2

2

7.39 ± 0.5

9.24 ± 0.7

3

35.62 ± 2.2

28.86 ± 1.9

4

76.79 ± 3.9

64.16 ± 3.6

5

13.46 ± 1.1

16.43 ± 1.3

7

41.91 ± 2.4

37.43 ± 2.1

8

63.78 ± 3.7

58.06 ± 3.2

9

91.00 ± 4.8

69.99 ± 3.7

  1. aIC50 (µM): 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and > 100 (non-cytotoxic). Data were displayed as mean ± SEM (n = 3, three independent repeats).
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