Table 2 RoB Tool V. 2 risk of bias assessment and GRADE certainty in evidence ratings per study.
From: Comparison of luteal support protocols in fresh IVF/ICSI cycles: a network meta-analysis
References | RoB Tool 2 | GRADE | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Random sequence generation | Allocation concealment | Performance bias | Detection bias | Attrition bias | Reporting bias | Other | Collectively | Risk of Bias | Imprecision | Inconsistency | Indirectness | Publication bias | Collectively | |
Gawron et al.25 | Low | Moderate | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kao et al.26 | Low | Moderate | Moderate | Moderate | Low | Moderate | Moderate | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Razieh et al.27 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Iwase et al.28 | Low | High | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Moini et al.29 | Unclear | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Madkour et al.30 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kara et al.31 | Low | Unclear | Low | Low | Low | Unclear | Unclear | 2 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Serna et al.32 | Low | Low | High | High | Low | Low | Low | 3 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Fatemi et al.33 | Low | High | High | High | Low | Low | High | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Kleinstein et al.34 | Low | Low | High | High | Low | Low | Unclear | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Zegers-Hochschild et al.35 | High | Unclear | Unclear | Unclear | Unclear | Low | Low | 3 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Andersen et al.36 | Low | High | Unclear | Unclear | Low | Low | Unclear | 3 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Artini et al.37 | High | Unclear | Unclear | Unclear | Unclear | Unclear | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Araujo et al.38 | High | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | 2 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Griesinger et al.39 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Goudge et al.40 | Low | Low | Unclear | Unclear | Low | Unclear | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Kohls et al.41 | Low | Low | High | High | Low | Low | Low | 2 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Kyrou et al.42 | Low | Low | High | High | Low | Low | Unclear | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Prietl et al.43 | High | High | Unclear | Unclear | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁◯◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁◯◯◯ |
Ceyhan et al.44 | Low | Low | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Farhi et al.45 | Low | Low | Unclear | Unclear | Low | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Engmann et al.46 | Low | Low | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Belaisch-Allart et al.47 | Low | Unclear | Unclear | Unclear | Unclear | Unclear | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kupferminc et al.48 | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Aghahosseini et al.49 | Low | High | High | High | Low | High | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Lin et al.50 | Low | Unclear | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Yanushpolsky51 | Low | Low | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Elgindy et al.52 | Low | Low | Unclear | Unclear | Low | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Isik et al.53 | Low | Low | Unclear | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Yildiz et al.54 | Low | Unclear | Unclear | Unclear | Low | High | Low | 3 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Dal Prato et al.55 | Low | Low | High | High | Low | Low | Low | 3 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Propst et al.56 | Unclear | Unclear | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Chakravarty et al.57 | Unclear | Unclear | Low | Unclear | Unclear | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Friedler et al.58 | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Pouly et al.59 | Low | Unclear | Unclear | Unclear | Low | Low | Unclear | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Salehpour et al.60 | Unclear | Unclear | High | High | Low | Low | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Bergh et al.61 | Low | Unclear | Unclear | Unclear | Low | Low | Unclear | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Doody et al.62 | Low | Low | High | Unclear | Low | Low | Low | 2 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Tay et al.63 | Unclear | Unclear | Unclear | Unclear | Unclear | Unclear | Low | 2 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Abate et al.64 | Unclear | Unclear | Unclear | Unclear | Unclear | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Abate et al.65 | Unclear | Unclear | Low | Low | Unclear | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Aboulghar et al.66 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Aghsa et al.67 | Low | Unclear | Unclear | Unclear | Low | Low | Low | 2 | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Ata et al.68 | Low | Low | Low | Low | Low | Unclear | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Baker et al.69 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Ganesh et al.70 | Low | High | Low | Low | Low | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Golan et al.71 | High | Unclear | Low | Low | High | Unclear | Unclear | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Inamdar et al.72 | Low | Low | Unclear | Unclear | Low | High | Low | 2 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Lockwood et al.73 | Low | Low | Unclear | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Martinez et al.74 | Low | Low | Low | Unclear | Unclear | Unclear | Low | 2 | ⨁⨁⨁⨁ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Patki et al.75 | Unclear | Unclear | Unclear | Unclear | Unclear | High | Unclear | 3 | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁⨁ | ⨁◯◯◯ |
Stadtmauer et al.76 | Low | High | Low | High | Unclear | Low | Unclear | 3 | ⨁⨁◯◯ | ⨁⨁◯◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁◯◯◯ |
Tesarik et al.77 | Low | Low | Low | High | Low | High | Unclear | 3 | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁⨁ | ⨁◯◯◯ |
Tournaye et al.78 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Michnova et al.79 | High | Unclear | Low | Low | Unclear | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Elgindy et al.80 | Low | Low | High | Unclear | Unclear | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Yang et al.81 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Tomic et al.82 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Gizzo et al.83 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kutlusoy et al.84 | High | Unclear | Unclear | Unclear | Low | Low | Low | 2 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Ozer et al.85 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Saharkhiz et al.86 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Horowitz et al.87 | Moderate | Moderate | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Belaisch-Allart et al.88 | Low | Moderate | High | High | Moderate | Moderate | Low | 3 | ⨁⨁◯◯ | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Chi et al.89 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Fusi et al.90 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Gorkemli et al.91 | Low | Moderate | Moderate | Moderate | Low | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Ibrahem et al.92 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kapur et al.93 | Moderate | Moderate | Moderate | Moderate | High | Moderate | Low | 3 | ⨁⨁◯◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ |
Khrouf et al.94 | Moderate | Moderate | Low | Low | Low | Moderate | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁◯◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Kwon et al.95 | Low | Moderate | Low | Low | Low | Moderate | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁◯◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Mele et al.96 | Moderate | Moderate | Moderate | Moderate | Low | Low | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Zargar et al.97 | Moderate | Moderate | Moderate | Moderate | Moderate | Moderate | Low | 2 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Pirard et al.98 | Moderate | Moderate | Moderate | Low | Low | Low | Low | 1 | ⨁⨁⨁◯ | ⨁⨁⨁◯ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁◯ |
Var et al.99 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
Humaidan100 | Low | Low | Low | Low | Low | Low | Low | 1 | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ | ⨁⨁⨁⨁ |
