Figure 2
From: Effects of an OX2R agonist on migration and removal of tau from mouse brain
Diurnal fluctuation of wakefulness, neuronal activation, and tau release in hippocampal ISF in wild-type mice. (a) Time schedule for EEG/EMG recordings in C57BL/6J mice. (b) Sleep/wake rhythm of C57BL/6J mice at 13 weeks old. Mean ± SEM; n = 9. (c) Time schedule of ISF sampling using in vivo microdialysis in C57BL/6J mice. The concentration of (d) tau, (e) lactate, and (f) glucose in ISF was expressed as a percentage of the average of the total fraction for 24 h in C57BL/6J mice. Mean ± SEM; n = 6. EEG electroencephalogram; EMG electromyogram; ISF interstitial fluid; SEM standard error of the mean; ZT zeitgeber time.
