Figure 4

Characterization of the sleep/wake rhythm of human P301S tau Tg mice at 7, 9, and 10 months old. (a) Time schedule for EEG/EMG recordings. For human P301S tau Tg mice at 7, 9, and 10 months old, (b, f, j) sleep/wake rhythm, (c, g, k) total wakefulness time, (d, h, l) episode number of wakefulness, and (e, i, m) episode duration of wakefulness were compared with nonTg mice. Mean ± SEM; n = 8. T-test *p < 0.05, **p < 0.01. EEG electroencephalogram; EMG electromyogram; ns not significant; SEM standard error of the mean; Tg transgenic; ZT zeitgeber time.