Figure 5
From: Effects of an OX2R agonist on migration and removal of tau from mouse brain
Effects of OX-201 at 3, 10, and 30 mg/kg on wakefulness time in human P301S tau Tg mice at 7 months old. (a) Time schedule for drug administration in human P301S tau Tg mice during the active phase. OX-201 was administered orally to mice at ZT12, and then EEG/EMG were recorded. Analysis was performed with data collected during 24 h after administration. (b) Effects of OX-201 at 3, 10, and 30 mg/kg on wakefulness time. Mean ± SEM; n = 6. (c) Effects of OX-201 on total wakefulness time for 24 h after administration as shown in 6-h groupings. Mean ± SEM; n = 6. William’s test *p < 0.05, ***p < 0.001. (d) Plasma concentrations of OX-201 in human P301S tau Tg mice and nonTg littermates at 7 months old. Mean ± SEM; n = 4. EEG electroencephalogram; EMG electromyogram; h hours; SEM standard error of the mean; Tg transgenic; WT wild type; ZT zeitgeber time.
