Figure 6
From: Effects of an OX2R agonist on migration and removal of tau from mouse brain
Effect of repeated administration of OX-201 on hippocampal tau levels in human P301S tau Tg mice. (a) Time schedule for drug administration in human P301S tau Tg and nonTg littermate mice. OX-201 at 30 mg/kg was administered orally to mice once daily during the active phase (ZT12) for 2 months. (b) Effects of repeated administration of OX-201 on tau levels in the hippocampus of human P301S tau Tg mice. Mean ± SEM; n = 7–8. T-test ***p < 0.001. ns not significant; SEM standard error of the mean; Tg transgenic; ZT zeitgeber time.
