Figure 5 | Scientific Reports

Figure 5

From: A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson’s disease

Figure 5

Effect of Lacticaseibacillus rhamnosus E9 administration on tight junction proteins and SOX-10 in ileum of MPTP-induced mouse model of PD compared to the control. (A) Immunohistochemical staining of ileal ZO-1 (100 ×), Occludin (100 ×) (staining intensity is evaluated in ideal mucosa), and SOX-10 (200 ×, inset-4000 ×) (Arrows are nuclear positivity in myenteric plexus). (B) Protein expression of ileal ZO-1, Occludin, and SOX-10 in PD and control mice. (C) Gene expression of ileal ZO-1 and Occludin in PD and control mice. MPTP mice were received (i.p.) 30 mg/kg MPTP-HCl daily for 5 consecutive days (MPTP and MPTP + P). Probiotic mice were administered 1 dose (108 CFU/mouse/day) daily of L. rhamnosus E9 for fifteen days and sacrificed after the last dose (P and MPTP + P). *p ≤ 0.05, control vs MPTP (n:4–5/group).

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