Figure 3
From: A novel insight into neurological disorders through HDAC6 protein–protein interactions
Schematic representation of HDAC6 domains and their protein targets with the indication of their binding sites. From N-terminal; Nuclear localization Signal (NLS), Nuclear Export Signal 1 (NES1), Deacetylase Domain 1 (DD1), Dynein Motor Binding (DMB), Deacetylase Domain (DD2), Ser-Glu-containing tetradecapeptide (SE14) repeat domain, Nuclear Export Signal 2 (NES2), and zinc-finger ubiquitin binding domain (ZnF-UBP), also known as Binder of Ubiquitin Zinc Finger (BUZ). To simplify the figure, subtypes of Alpha and Beta tubulin proteins are not visualized; Alpha and Beta tubulins are visualized as TUBA and TUBB respectively. Similarly, dynein isoforms, DYNLL1 and DYNC1H1, are shown both as Dynein. MAPK3 protein, also known as ERK-1, binds to phosphorylation sites on HDAC6 at threonine 1031 and serine 1035 which are close to SE14 domain. SOD1 was identified to interact with HDAC6 between DD2 and SE14. Besides individual proteins exhibited here, there are also two protein complexes, HSP90-HSF1 and KAT5-EP400 presented with their binding sites in Znf-UBP and DD1 and DD2 domains, respectively. aa, amino acid.
