Table 4 Cox proportional hazards regression analysis for the risk of herpes zoster in different type of obesity.

From: The risk of herpes zoster is positively associated with obesity, especially morbid obesity

Variables

Obesity

cHR

(95% CI)

p-value

aHR

(95% CI)

p-value

Non-morbid obesity

Morbid obesity

Event

PY

IR

Event

PY

IR

Gender

 Female

649

78,179

8.30

71

10,710

6.63

1.06

(0.83, 1.35)

0.66

1.36

(1.06, 1.74)*

0.02

 Male

341

50,015

6.82

54

7906

6.83

1.38

(1.04, 1.84)*

0.03

1.66

(1.24, 2.23)***

 < 0.001

Age, year

 20–29

72

21,997

3.27

17

5171

3.29

1.29

(0.76, 2.19)

0.35

1.30

(0.76, 2.20)

0.34

 30–39

155

31,845

4.87

26

5819

4.47

1.27

(0.83, 1.93)

0.27

1.28

(0.84, 1.95)

0.25

 40–49

215

31,105

6.91

33

3898

8.47

1.55

(1.07, 2.24)*

0.02

1.59

(1.10, 2.30)*

0.01

 ≥ 50

548

43,246

12.67

49

3729

13.14

1.62

(1.21, 2.18)**

0.00

1.58

(1.18, 2.12)**

0.00

Comorbidities

 Without comorbidities

521

84,674

6.15

74

13,002

5.69

1.16

(0.91, 1.48)

0.23

1.40

(1.10, 1.80)**

0.01

 With comorbiditiesa

469

43,519

10.78

51

5614

9.08

1.39

(1.04, 1.87)*

0.03

1.57

(1.17, 2.11)**

0.00

  DM

   No

655

97,152

6.74

92

14,423

6.38

1.20

(0.97, 1.50)

0.10

1.48

(1.18, 1.84)***

 < 0.001

   Yes

335

31,042

10.79

33

4193

7.87

1.24

(0.87, 1.78)

0.24

1.47

(1.02, 2.12)*

0.04

  CKD

   No

968

126,485

7.65

122

18,392

6.63

1.16

(0.96, 1.41)

0.11

1.45

(1.20, 1.75)***

 < 0.001

   Yes

22

1708

12.88

3

224

13.39

2.23

(0.63, 7.86)

0.21

2.61

(0.69, 9.83)

0.16

  CAD

   No

735

108,854

6.75

93

16,107

5.77

1.13

(0.91, 1.40)

0.28

1.42

(1.14, 1.76)**

0.00

   Yes

255

19,340

13.19

32

2510

12.75

1.55

(1.07, 2.25)*

0.02

1.62

(1.11, 2.35)*

0.01

  Cancer

   No

965

125,649

7.68

121

18,324

6.60

1.16

(0.96, 1.40)

0.13

1.45

(1.20, 1.76)***

 < 0.001

   Yes

25

2544

9.83

4

292

13.70

2.83

(0.93, 8.58)

0.07

2.36

(0.74, 7.52)

0.14

  1. aIndividuals with any comorbidity of diabetes mellitus (DM), chronic kidney disease (CKD), coronary artery disease (CAD), cancer were classified into the comorbidity group; PY person-year, IR incidence rate, per 1000 person-years, cHR crude hazard ratio, aHR adjusted hazard ratio, adjusted for age, sex, index year, diabetes, chronic kidney disease, coronary artery disease, and cancer, CI confidence interval; *p < 0.05, **p < 0.01, ***p < 0.001.