Figure 2

Dendrogram of 342 holo-structures of Mpro based on alpha-carbon atom coordinates of interacting amino acids (A). The red line represents the threshold (1.2Â Ã…) in the RMSD used to identify clusters. The chemical diversity of ligands within each cluster is depicted in (B). Clusters 1 and 2 are not presented, as each cluster consists of only one Mpro structure.