Figure 6 | Scientific Reports

Figure 6

From: Postpartum development of metabolic dysfunction-associated steatotic liver disease in a lean mouse model of gestational diabetes mellitus

Figure 6

PP30 liver weight, lipid content and liver morphology. (A) Liver weight presented as percentage of body weight. (B) Hepatic triglycerides. (C) Hepatic phospholipids. (D) Hepatic TG/PLs ratios. (E) Hepatic total cholesterol. (F) Hepatic free cholesterol. (G) Hepatic esterified cholesterol contents. (H) Hepatic glycogen. (I) MASLD activity score (MAS), compromising of lobular inflammation, steatosis, grade, and ballooning. (J) Anisokaryosis derived from the pathological assessment of liver H&E slides. (K) Apoptotic scores derived from pathological assessment of H&E-stained liver tissue sections. (L) Mitotic figure scores derived from pathological assessment of H&E-stained liver tissue sections. (M) Representative images of H&E- and PAS-stained liver sections. LF low-fat diet, HF high-fat diet, GDM gestational diabetes mellitus, LF: n = 10, HF: n = 12, GDM: n = 13. Data are presented as the mean ± SD. (A–J,L–M) Kruskal–Wallis test followed by Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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