Figure 5 | Scientific Reports

Figure 5

From: CD248-expressing cancer-associated fibroblasts induce epithelial–mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages

Figure 5

Fibroblasts-specific CD248 depletion inhibited Lung cancer (LC) EMT process in vivo. 5 × 105 LLC cells injected into cd248fl/flfsp-1+/+ (WT) and cd248fl/flfsp-1cre/+ (cKO) mice to establish a LC metastasis model (n = 4 per group). (A) An illustration of the murine model. (B) Fluorescence intensity assessment per cohort. Data provided as mean ± SEM. p < 0.0001. (C,D) Images of the xenografts after inoculation with the LLC in WT and cKO mice. (E) Dual-IF staining results depicting the CD248 (green), N-cadherin (pink) and E-cadherin (red) in tumor tissue of WT and cKO mice. Scale bar, left: 100 μm; right: 20 μm.

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