Table 7 Predictions of organ-specific toxicity using ProTox II.
Classification | Target | Chitosan | ZnO NPs | Chitosan/ZnO | |||
|---|---|---|---|---|---|---|---|
Prediction | Probability | Prediction | Probability | Prediction | Probability | ||
Organ toxicity | Hepatotoxicity | Inactive | 0.74 | Inactive | 0.97 | Inactive | 0.97 |
Toxicity endpoints | Carcinogenicity | Inactive | 0.69 | Inactive | 0.66 | Inactive | 0.57 |
Immunotoxicity | Inactive | 0.83 | Inactive | 0.99 | Inactive | 0.99 | |
Mutagenicity | Inactive | 0.62 | Inactive | 0.59 | Inactive | 0.85 | |
Cytotoxicity | Inactive | 0.65 | Inactive | 0.79 | Inactive | 0.78 | |
Tox21-Nuclear receptor signaling pathways | Aryl hydrocarbon receptor (AhR) | Inactive | 0.97 | Inactive | 0.97 | Inactive | 1.0 |
Androgen receptor (AR) | Inactive | 0.92 | Inactive | 1.0 | Inactive | 1.0 | |
Androgen receptor ligand binding domain (AR-LBD) | Inactive | 0.96 | Inactive | 0.88 | Inactive | 0.99 | |
Aromatase | Inactive | 0.98 | Inactive | 0.93 | Inactive | 0.82 | |
Estrogen receptor alpha (ER) | Inactive | 0.69 | Inactive | 0.94 | Inactive | 0.99 | |
Estrogen receptor ligand binding domain (ER-LBD) | Inactive | 0.94 | Inactive | 0.86 | Inactive | 1.0 | |
Peroxisome proliferator-activated receptor gamma (PPAR-Gamma) | Inactive | 0.99 | Inactive | 0.86 | Inactive | 0.99 | |
Tox21-Stress response pathways | Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE) | Inactive | 0.98 | Inactive | 0.79 | Inactive | 0.99 |
Heat shock factor response element (HSE) | Inactive | 0.98 | Inactive | 0.79 | Inactive | 0.99 | |
Mitochondrial membrane potential (MMP) | Inactive | 0.95 | Inactive | 0.95 | Inactive | 0.83 | |
Phosphoprotein (tumor suppressor) p53 | Inactive | 0.95 | Inactive | 0.89 | Inactive | 0.99 | |
ATPase family AAA domain-containing protein 5 (ATAD5) | Inactive | 0.98 | Inactive | 0.88 | Inactive | 0.99 | |
