Table 1 The chemistry of isolated sesquiterpenoids (SQs) and sesquiterpenoid dimers (SQDs) along with their activity against human and murine TLR4.
Compounds | Type | Activity |
|---|---|---|
10β,11-dihydroxy-1β-hydroperoxide-4αH,5αH,7βH-guaiane (1) | Guaiane | Inactive |
(1S*,4S*,5R*,10S*)-guai-6-ene-10β-ol (2) | ||
Guaianediol (3) | ||
4α,10α,11-trihydroxy-1βH,5βH-guai-7(8)-ene (4) | Partial antagonist mTLR4 | |
Spathulenol (5) | Aromadendrane | Inactive |
4β-10α-dihydroxyaromadendrane (6) | Antagonist TLR4 | |
10β-hydroxy-4α,4β-dimethyl-5αH,7αH-eudesm-3-one (7) | Eudesmane | |
α-cadinol (8) | Cadinane | Inactive |
10-hydroxyl-15-oxo-α-cadinol (9) | Partial antagonist TLR4 | |
Dysotican A (10) | ||
Dysotican B (11) | Antagonist mTLR4 | |
2,15-dihydroxycalamenene (12) | Contrasting effect | |
Schiffnerone B (13) | Tris-nor-cadinane | Inactive |
Aristegelone A (14) | Contrasting effect | |
Eudesm-4(15)-ene-1β,6α-diol (15) | Eudesmane | Partial antagonist mTLR4 |
Eudesm-4(15)-ene-1β,6β-diol (16) | Contrasting effect | |
Dysotican C (17) | Asymmetrical cadinane-dimer | Antagonist TLR4 |
Dysotican D (18) | Asymmetrical guaiane-dimer | Partial antagonist mTLR4 |
Dysotican E (19) | Hybrid eudesmane/germacrene-dimer | |
Dysotican F (20) | Asymmetrical cadinane-dimer | |
Dysotican G (21) | Symmetrical cadinane-dimer | Inactive |
Dysotican H (22) | Antagonist TLR4 |
