Table 2 The number of potential drug targets identified for targeting five microorganisms while conserving one microorganism. Available potential solutions decreased drastically compared to the number of potential solutions for targeting all six microorganisms (the first row).
From: Systematic analysis of microorganisms’ metabolism for selective targeting
Name of the conserved strain | Number of potential solutions | ||||
|---|---|---|---|---|---|
Single essentials | Double SLs | Triple SLs | Quadruple SLs | Total solutions | |
no conservation | 31 | 196 | 731 | 1,033 | 1,991 |
Y. pestis | 19 | 0 | 1 | 31 | 51 |
S. dysenteriae | 0 | 0 | 7 | 3 | 10 |
S. enterica | 0 | 0 | 0 | 0 | 0 |
E. coli | 3 | 12 | 27 | 16 | 58 |
P. putida | 9 | 5 | 31 | 16 | 61 |
K. pneumoniae | 19 | 3 | 0 | 17 | 39 |
