Table 3 Uptake (SUV) and biodistribution of [18F]2 and [18F]2 with 20 µg of 2 in whole body of wild-type FVB/NJ mice at 5 min, 10 min and 120 min post intravenous (i.v.) administration assessed by ex vivo biodistribution.

From: Synthesis and preliminary evaluation of novel PET probes for GSK-3 imaging

Organ

[18F]2

[18F]2 + 

20 µg of 2

[18F]2

[18F]2 + 

20 µg of 2

[18F]2

[18F]2 + 

20 µg of 2

5 min post-injection

5 min post-injection

10 min post-injection

10 min post-injection

120 min post-injection

120 min post-injection

SUV, Average ± SD (n = 4)

SUV, Average ± SD (n = 3)

SUV, Average ± SD (n = 4)

SUV, Average ± SD (n = 3)

SUV, Average ± SD(n = 3)

SUV, Average ± SD (n = 3)

Cerebellum

0.75 ± 0.49

0.62 ± 0.03

0.30 ± 0.05

0.39 ± 0.15

0.05 ± 0.02

0.18 ± 0.03*

Brain stem

0.81 ± 0.49

0.66 ± 0.03

0.34 ± 0.06

0.44 ± 0.15

0.06 ± 0.03

0.22 ± 0.04*

Thalamus

0.84 ± 0.51

0.65 ± 0.04

0.34 ± 0.07

0.44 ± 0.10

0.05 ± 0.03

0.20 ± 0.04*

Hippocampus

1.14 ± 0.74

0.78 ± 0.06

0.47 ± 0.15

0.45 ± 0.18

0.08 ± 0.05

0.24 ± 0.09*

Cortex

0.79 ± 0.50

0.65 ± 0.02

0.32 ± 0.07

0.43 ± 0.10

0.05 ± 0.03

0.19 ± 0.03*

CN

0.87 ± 0.48

0.65 ± 0.04

0.34 ± 0.07

0.45 ± 0.05*

0.06 ± 0.02

0.19 ± 0.03*

Lung

0.65 ± 0.35

1.17 ± 0.15*

0.48 ± 0.03

1.08 ± 0.15*

0.18 ± 0.07

0.52 ± 0.09*

Heart

0.69 ± 0.36

1.38 ± 0.11*

0.45 ± 0.02

1.14 ± 0.16*

0.16 ± 0.08

0.48 ± 0.12*

Liver

11.85 ± 0.33

8.37 ± 0.36

14.43 ± 1.48

7.85 ± 0.41*

3.08 ± 1.44

4.00 ± 0.22

Left kidney

1.37 ± 0.69

2.47 ± 0.30*

1.01 ± 0.16

2.27 ± 0.32*

0.54 ± 0.06

2.18 ± 0.51*

Right kidney

1.34 ± 0.69

2.46 ± 0.18*

0.97 ± 0.12

2.30 ± 0.35*

0.48 ± 0.15

2.30 ± 0.81*

Spleen

0.74 ± 0.27

1.00 ± 0.05

0.55 ± 0.20

1.14 ± 0.50*

0.15 ± 0.07

0.44 ± 0.11*

Pancreas

1.27 ± 0.56

1.83 ± 0.16

0.85 ± 0.23

1.53 ± 0.15*

0.22 ± 0.09

0.57 ± 0.15*

Muscle

0.47 ± 0.23

0.90 ± 0.17*

0.43 ± 0.03

0.72 ± 0.09*

0.11 ± 0.04

0.32 ± 0.06*

Bone

0.30 ± 0.14

0.48 ± 0.02

0.29 ± 0.04

0.50 ± 0.03*

1.08 ± 0.33

1.22 ± 0.31

Urine

0.10 ± 0.10

0.20 ± 0.29

1.78 ± 1.21

0.85 ± 0.79*

20.55 ± 8.76

3.20 ± 2.32

Bladder

0.40 ± 0.12

0.71 ± 0.09*

0.48 ± 0.08

0.84 ± 0.13*

1.58 ± 1.90

0.73 ± 0.54

Blood

0.38 ± 0.18

0.93 ± 0.14*

0.34 ± 0.02

0.79 ± 0.12*

0.15 ± 0.07

0.43 ± 0.07*

Stomach

0.80 ± 0.24

0.86 ± 0.32

0.53 ± 0.09

0.97 ± 0.63

0.68 ± 0.41

1.28 ± 1.08

Skin

0.46 ± 0.17

0.66 ± 0.16

0.52 ± 0.16

0.66 ± 0.10

0.10 ± 0.04

0.71 ± 0.66

Adipose

0.29 ± 0.09

0.33 ± 0.05

0.24 ± 0.07

0.38 ± 0.05*

0.14 ± 0.04

0.25 ± 0.05*

Feces

0.36 ± 0.12

0.79 ± 0.17*

0.51 ± 0.05

1.06 ± 0.21*

2.77 ± 0.79

3.25 ± 0.96

SI

1.94 ± 1.12

3.12 ± 0.27*

3.33 ± 0.49

3.22 ± 0.15*

5.22 ± 0.09

10.72 ± 1.95*

LI

1.09 ± 0.45

1.47 ± 0.17

0.80 ± 0.06

1.48 ± 0.31*

0.57 ± 0.32

1.22 ± 0.63

Cecum

0.54 ± 0.07

0.73 ± 0.03*

0.54 ± 0.03

0.93 ± 0.16*

4.67 ± 4.60

1.79 ± 0.60

Eyes

0.30 ± 0.12

0.35 ± 0.05

0.20 ± 0.03

0.36 ± 0.04*

−

0.29 ± 0.09

  1. CN caudate nucleus; SI small intestine; LI large intestine.
  2. *P < 0.05 [18F]2 vs [18F]2 + 20 µg of 2.
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