Figure 5
From: Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization
TGF-β3 and kartogenin have different chondro-inducive effects in 2D and 3D. (a) (i) DNA concentration, (ii) sGAG concentration and (iii) sGAG/DNA performed on Y201 cells cultured in monolayer (2D) indicate the potential chondro-inducive behavior of kartogenin in a 2D model (***p < 0.001; ****p < 0.0001). (b) (i) DNA content, (ii) sGAG production and (iii) sGAG/DNA performed on Y201 cells cultured in the Wnt3a platform/GelMA system indicate that TGF-β3 is chondro-inducive, while kartogenin does not enhance differentiation compared to basic condition in the 3D model (*p < 0.05; **p < 0.01; ****p < 0.0001).
