Table 1 Formulation runs of factors and responses used for optimization by Box-Behnken design.
From: Posaconazole-hemp seed oil loaded nanomicelles for invasive fungal disease
Run | Factor (A) | Factor (B) | Factor (C) | Response 1 | Response 2 | Response 3 |
|---|---|---|---|---|---|---|
PLGA Conc. (%) | Surfactant (mg/mL) | Stirring time (min) | Size | PDI | Entrapment efficiency (%) | |
1 | 1.25 | 3 | 165 | 173.4 | 0.22 | 92.77 |
2 | 0.75 | 3 | 165 | 159.98 | 0.18 | 92 |
3 | 1.25 | 1 | 90 | 185.7 | 0.3 | 89.23 |
4 | 1 | 1 | 165 | 171.2 | 0.32 | 91.46 |
5 | 0.75 | 1 | 90 | 174.2 | 0.28 | 92.87 |
6 | 1 | 5 | 165 | 162.1 | 0.2 | 93.18 |
7 | 1.25 | 3 | 15 | 175.3 | 0.31 | 91 |
8 | 1 | 5 | 15 | 171.3 | 0.47 | 92.02 |
9 | 0.75 | 5 | 90 | 170.5 | 0.32 | 91.72 |
10 | 1.25 | 5 | 90 | 164.9 | 0.25 | 93.98 |
11 | 1 | 3 | 90 | 174.1 | 0.29 | 93.71 |
12 | 1 | 1 | 15 | 188.1 | 0.36 | 89.7 |
13 | 0.75 | 3 | 15 | 184.4 | 0.4 | 91.18 |
Opt. run | 1 | 3 | 90 | 165 | 0.08 | 93.2 |
