Figure 5 | Scientific Reports

Figure 5

From: Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure

Figure 5

Analysis of the network-inferred miRNA-mRNA interactions. (a) Proportion of inferred miRNA-mRNA interactions that are computationally predicted (miRDIP) at various confidence classes. NA indicates network interactions not present in the miRDIP database. (b) The degree (number of mRNA targets) of 23 short-listed miRNAs with inferred miRNA-mRNA interactions at > 1 time-point (num. timept). The degree is z-score normalised along time-points – the miRNA with most mRNA targets at each time-point is dark red. Hatched fill indicates that the miRNA had no inferred mRNA targets at that time-point (NA). miRNAs were clustered by hierarchical clustering. (c) mRNAs dysregulated in > 1 time-point and targeted by > 2 of the 23 short-listed miRNAs across the time-course. Red shading indicates the number of miRNAs targeting each mRNA at each time-point.

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