Figure 1
From: Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain
Physiological effect of CFN at 50, 100, and 300 ng/kg. (A) Dynamic blood PCO2 levels significantly increased at higher doses, indicating CFN induced respiratory depression. Arterial blood PCO2 defined as percent change from baseline (n = 3 at 50 ng/kg, n = 6 at 100 and 300 ng/kg). (B) Peak respiratory response defined as the average percent change from baseline between t = 5 to t = 15 min after CFN injection. (C) Dynamic HR change from baseline over time at 50 (n = 3), 100 (n = 6), and 300 ng/kg (n = 6). (D) Peak cardiac response defined as the average percent change from baseline between t = 5 to t = 15 min after CFN administration. All values reported as mean ± SEM. Significance reported using one-sample one-tailed Student’s t-test (*p < 0.05, **p < 0.01, ***p < 0.001).
