Table 4 Diagnostic performance of different methods, including culture, Xpert MTB/RIF, and nucleotide MALDI-TOF assay on BALFs from the clinical susceptible smear-negative PTB patients using clinical diagnosis as reference.

From: Enhanced diagnosis of pulmonary tuberculosis through nucleotide MALDI-TOF MS analysis of BALF: a retrospective clinical study

Test method

Results of MTB

Clinical diagnosis

Sensitivity (%, 95%CI)

Specificity (%, 95%CI)

PPV (%, 95%CI)

NPV (%, 95%CI)

Accuracy (%, 95%CI)

PTB (212)

non-PTB (64)

MGIT 960 culture (n = 217)

Positive

46

4

25.4 (19.2–32.4)

88.9 (73.9–96.9)

92. 0 (80.8–97.8)

19.2 (13.5–26. 0)

35.9 (29.6–42.7)

Negative

135

32

     
   

p < 0.001

p = 0.986

p > 0.99

p = 0.002

p < 0.001

Xpert MTB/RIF (n = 178)

Positive

43

0

30.7 (23.2–39.1)

100.0 (90.7–100.0)

100.0 (91.8–100.0)

28.1 (20.8–36.5)

45.5 (38.0–53.1)

Negative

97

38

     
   

p < 0.001

p = 0.667

p = 0.872

p = 0.125

p = 0.012

nucleotide MALDI-TOF MS (n = 276)

Positive

138

10

65.1 (58.3–71.5)

84.4 (73.1–92.2)

93.2 (87.9–96.7)

42.2 (33.5–51.2)

69.6 (63.8–74.9)

Negative

74

54

     
   

ref

ref

ref

ref

ref

  1. PTB pulmonary tuberculosis, non-PTB non-pulmonary tuberculosis, PPV positive predictive value, NPV negative predictive value, CI confidence interval, Ref reference.
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