Figure 5
From: Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction
Activation kinetics of TREK-1 channel by PUFAs. (A–C) Time course showing the effects of 10 µM PUFAs and ML402 on ITREK-1 at 0 mV. PUFAs and ML402 were superfused until the steady-state was reached. Insets show the representative current densities recorded in control medium and then under PUFAs or ML402 application. (D) Lack of correlation between the half-activation and the acyl chain length of PUFAs (Spearman correlation test : p-value > 0.99). (E) Relationship between the fold-increase of TREK-1 (IPUFA/I0) and the half-activation (min) (r = −0.93; p-value = 0.002; error barres show the SEM of the IPUFA/I0 and the half-activation).
