Table 3 Parameters of the activation kinetic of TREK-1 by PUFAs and ML402 in whole-cell configuration of patch-clamp.

From: Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

 

n

Half-activation (min)

Statistical differences

Steady-state (min)

Mean ± SEM

 

Mean ± SEM

C18:2 n-6

20

1.86 ± 0.16

a

3.65 ± 0.28

C20:2 n-6

7

4.61 ± 0.30

b,c

7.40 ± 0.25

C20:4 n-3

12

4.56 ± 0.24

b,c

7.13 ± 0.23

C20:4 n-6

16

3.97 ± 0.31

b,c

6.67 ± 0.34

C20:5 n-3

17

3.18 ± 0.30

b,c

5.65 ± 0.33

C22:5 n-6

11

3.12 ± 0.30

a,c

5.31 ± 0.41

C22:5 n-3

12

4.18 ± 0.35

b,c

5.95 ± 0.37

C22:6 n-3

20

2.26 ± 0.19

a

4.34 ± 0.27

ML402

19

2.11 ± 0.16

a

3.86 ± 0.33

  1. Values indicate the half-activation time (min) and the steady-state (min) of the activation of TREK-1. The statistical comparison of the half-activation time for each PUFAs was performed with a Kruskal–Wallis test followed with the post-hoc Dunn’s test. Two rows having the same letter are not significantly different. Data are expressed as mean \(\pm \) SEM.
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