Table 3 General demographic data of subjects in longitudinal follow-up.
Characteristics | Whole sample (n = 506) | NC-aMCI (n = 136) | NC-NC (n = 370) | p value |
|---|---|---|---|---|
Age, years (SD) | 69.23 (7.22) | 71.26 (6.81) | 68.48 (7.23) | 0.009* |
Education, years (SD) | 11.39 (3.37) | 10.67 (3.97) | 11.66 (3.08) | 0.050 |
Male, n(%) | 182 (36.0) | 56 (41.2) | 126 (34.1) | 0.145 |
Hypertension, n (%) | 289 (57.1) | 77 (56.6) | 212 (57.3) | 0.919 |
Diabetes, n (%) | 126 (24.9) | 40 (29.4) | 86 (23.2) | 0.165 |
CHD, n (%) | 68 (13.4) | 23 (16.9) | 45 (12.2) | 0.186 |
Hyperlipidemia, n (%) | 200 (39.5) | 55 (40.4) | 145 (39.2) | 0.838 |
Cerebral hemorrhage, n (%) | 9 (1.8) | 2 (1.5) | 7 (1.9) | 1.000 |
Stroke, n (%) | 79 (15.6) | 21 (15.4) | 58 (15.7) | 1.000 |
Depression, n (%) | 10 (2.0) | 2 (1.5) | 8 (2.2) | 1.000 |
NfL, pg/ml, mean (SD) | 17.54 (11.21) | 20.25 (12.46) | 16.54 (10.55) | 0.001* |
Ptau181, pg/ml, mean (SD) | 2.79 (2.08) | 3.07 (2.52) | 2.69 (1.89) | 0.033* |
T-tau, pg/ml, mean (SD) | 2.46 (2.39) | 2.46 (2.52) | 2.45 (2.34) | 0.665 |
Aβ42, pg/ml, mean (SD) | 11.36 (3.05) | 11.85 (3.18) | 11.18 (2.99) | 0.024* |
Aβ40,pg/ml, mean (SD) | 174.97 (45.12) | 181.81 (47.59) | 172.45 (43.98) | 0.027* |
Aβ42/ 40, mean (SD) | 0.07 (0.02) | 0.07 (0.03) | 0.07 (0.02) | 0.907 |
Baseline MoCA, mean (SD) | 24.52 (2.89) | 23.54 (3.24) | 24.88 (2.67) | 0.002* |
Follow up MoCA, mean (SD) | 23.51 (3.73) | 19.93 (3.36) | 24.82 (2.91) | < 0.001* |
