Table 1 Spray drying Parameter & Characteristics of Blank (YDGP) β-glucan particle.
From: Rifabutin loaded inhalable β-glucan microparticle based drug delivery system for pulmonary TB
Blank | Inlet Temp (°C) | Aspirator (%) | Outlet Temp (°C) | Pump Flow rate (ml/min) | Yield in (gram) | Yield in (%) | Polymer Drug ratio (gram) | Leucine conc. in (mg)/gram |
|---|---|---|---|---|---|---|---|---|
YDGP-A | 145 | 50 | 45 | 5 | 3.48 | 17.5 | 1:1 | 100 |
YDGP-B | 150 | 50 | 50 | 5 | 4.08 | 20.5 | 1:1 | 200 |
YDGP-C | 155 | 50 | 55 | 5 | 4.48 | 22.5 | 1:1 | 300 |
Drug | d0.1 (µm) | d0.5 (µm) | d0.9 (µm) | Drug loading efficiency (%) | MMAD (μm) | GSD (μm) | ||
|---|---|---|---|---|---|---|---|---|
Characteristics of Rifabutin drug loaded (DYDGP) β-glucan particle | ||||||||
DYDGP-A | 0.210 | 5.800 | 19.315 | 67 | 1.58 | 1.43 | ||
DYDGP-B | 0.374 | 4.320 | 6.341 | 68 | 2.07 | 1.81 | ||
DYDGP-C | 0.908 | 1.413 | 3.496 | 70 | 1.02 | 1.63 | ||
