Figure 3
Functional Enrichment Characteristic of distinct AD dataset. (A) Dot plot displays the KEGG pathway analysis results in the DEGs of the blood dataset. (B) A gene set enrichment analysis of the blood dataset is presented. The top four upregulated signatures and four downregulated signatures are shown. (C) The Venn diagram illustrates the overlap between DEGs of three brain tissue datasets. (D) KEGG results of the intersection obtained from (C). (E) The heatmap shows the common upregulated pathways and downregulated pathways shared between the entorhinal cortex, hippocampus, and superior frontal gyrus. Numbers within the boxes represent the normalized enrichment score (NES) score, using GSEA analysis. Upregulations are color-coded in red, whereas downregulations are marked in blue. Permission has been obtained from Kanehisa laboratories for using KEGG pathway database25
