Table 3 Adrenal and gonadal steroid concentrations of healthy males, 18 -35 years of age.

From: Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens

STEROID

nmol/L

Overall (n = 70)

DHEA > 7 nmol/L (n = 47)

DHEA < 7 nmol/L (n = 23)

P-value

Dehydroepiandrosterone (DHEA)_

 Mean (SD)

12.1 (9.07)

16.1 (8.58)

4.04 (1.44)

 < 0.001

 Median (Q1, Q3)

9.64 (5.19, 18.1)

13.5 (9.64, 20.6)

3.45 (3.45, 5.09)

 

 Min–Max

0.487–52.7

6.93–52.7

0.487–6.64

 

Androstenediol (A5)

 Mean (SD)

4.40 (2.44)

4.79 (2.79)

3.59 (1.13)

0.107

 Median (Q1, Q3)

3.40 (3.40, 4.88)

3.77 (3.40, 5.98)

3.40 (3.40, 3.87)

 

 Min–Max

0.479–13.4

0.479–13.4

1.24–6.68

 

Androstenedione (A4)

 Mean (SD)

1.63 (1.65)

1.71 (1.86)

1.44 (1.07)

0.713

 Median (Q1, Q3)

1.08 (0.350, 2.47)

0.942 (0.350, 2.51)

1.15 (0.537, 2.17)

 

 Min–Max

0.0651–7.53

0.0651–7.53

0.168–4.25

 

Testosterone (T)

 Mean (SD)

24.5 (6.85)

25.5 (6.60)

22.6 (7.08)

0.148

 Median (Q1, Q3)

24.3 (20.3, 28.9)

25.3 (21.3, 29.5)

22.8 (18.5, 28.0)

 

 Min–Max

7.76–47.3

7.76–47.3

7.81–35.4

 

Dihydrotestosterone (DHT)

 Mean (SD)

1.23 (2.90)

1.30 (3.01)

1.07 (2.73)

1

 Median (Q1, Q3)

0.170 (0.170, 0.170)

0.170 (0.170, 0.170)

0.170 (0.170, 0.334)

 

 Min–Max

0.0506–15.2

0.0506–15.2

0.114–11.4

 

11α-hydroxyandrostenedione (11OHA4)

 Mean (SD)

3.37 (1.75)

4.04 (1.62)

2.00 (1.13)

 < 0.001

 Median (Q1, Q3)

3.39 (2.09, 4.14)

3.80 (3.17, 4.61)

1.95 (1.12, 2.63)

 

 Min–Max

0.330–10.4

1.87–10.4

0.330–4.15

 

11-ketoandrostenedione (11KA4)

 Mean (SD)

0.764 (0.365)

0.838 (0.361)

0.611 (0.332)

0.010

 Median (Q1, Q3)

0.747 (0.382, 1.01)

0.811 (0.607, 1.05)

0.552 (0.330, 0.777)

 

 Min–Max

0.300–1.79

0.330–1.79

0.300–1.27

 

11α-hydroxytestosterone (11OHT)

 Mean (SD)

0.567 (0.518)

0.665 (0.590)

0.367 (0.225)

0.006

 Median (Q1, Q3)

0.481 (0.285, 0.670)

0.524 (0.366, 0.738)

0.360 (0.212, 0.505)

 

 Min–Max

0.0300–3.21

0.0879–3.21

0.0300–0.891

 

11-ketotestosterone (11KT)

 Mean (SD)

0.440 (0.328)

0.446 (0.318)

0.427 (0.354)

0.748

 Median (Q1, Q3)

0.330 (0.303, 0.464)

0.330 (0.306, 0.530)

0.330 (0.299, 0.419)

 

 Min–Max

0.0127–1.57

0.0127–1.57

0.0258–1.50

 

Pregnenolone (P5)

 Mean (SD)

3.57 (0.978)

3.76 (1.12)

3.18 (0.395)

0.007

 Median (Q1, Q3)

3.10 (3.10, 3.63)

3.10 (3.10, 4.14)

3.10 (3.10, 3.10)

 

 Min–Max

2.72–7.63

2.72–7.63

3.10–4.99

 

17α-hydroxypregnenolone (17OHP5)

 Mean (SD)

6.94 (5.86)

8.80 (6.34)

3.13 (1.10)

 < 0.001

 Median (Q1, Q3)

4.52 (3.00, 8.12)

7.37 (3.45, 11.9)

3.00 (3.00, 3.00)

 

 Min–Max

0.139–29.3

0.139–29.3

1.03–7.53

 

Progesterone (P4)

 Mean (SD)

0.101 (0.209)

0.128 (0.243)

0.0464 (0.0932)

0.406

 Median (Q1, Q3)

0 (0, 0.0707)

0 (0, 0.127)

0 (0, 0)

 

 Min–Max

0–0.839

0–0.839

0–0.271

 

17α-hydroxyprogesterone (17OHP4)

 Mean (SD)

0.644 (0.771)

0.511 (0.473)

0.916 (1.13)

0.308

 Median (Q1, Q3)

0.300 (0.300, 0.627)

0.300 (0.300, 0.565)

0.300 (0.300, 1.28)

 

 Min–Max

0.101–4.74

0.133–2.37

0.101–4.74

 

16α hydroxyprogesterone (16OHP4)_

 Mean (SD)

0.591 (0.424)

0.725 (0.430)

0.319 (0.248)

 < 0.001

 Median (Q1, Q3)

0.520 (0.316, 0.763)

0.628 (0.452, 0.828)

0.245 (0.136, 0.432)

 

 Min–Max

0–2.30

0.183–2.30

0–0.923

 

Cortisol_

 Mean (SD)

338 (150)

396 (119)

218 (137)

 < 0.001

 Median (Q1, Q3)

339 (224, 465)

359 (311, 488)

183 (117, 254)

 

 Min–Max

58.8–634

192–634

58.8–591

 

Corticosterone (CORT)

 Mean (SD)

14.1 (12.1)

18.2 (11.6)

5.73 (8.18)

 < 0.001

 Median (Q1, Q3)

7.83 (4.93, 22.7)

16.1 (6.98, 27.1)

2.55 (1.50, 6.73)

 

 Min–Max

0.530–42.9

3.83–42.9

0.530–39.0

 

Cortisone_

 Mean (SD)

55.8 (17.4)

59.6 (12.4)

47.8 (23.0)

0.006

 Median (Q1, Q3)

56.5 (45.4, 66.1)

60.6 (50.9, 66.5)

47.9 (31.4, 62.7)

 

 Min–Max

17.8–108

35.1–85.1

17.8–108

 

11-dehydrocorticosterone (11-DHCORT)_

 Mean (SD)

4.40 (2.31)

5.26 (2.01)

2.65 (1.88)

 < 0.001

 Median (Q1, Q3)

4.48 (2.45, 5.82)

5.14 (3.96, 6.71)

2.04 (1.45, 3.00)

 

 Min–Max

0.470–10.6

1.43–10.6

0.470–7.77

 

Cortisol:cortisone

 Mean (SD)

6.20 (2.97)

6.98 (2.86)

4.62 (2.59)

 < 0.001

 Median (Q1, Q3)

5.33 (4.06, 7.73)

6.59 (4.79, 8.58)

3.63 (3.27, 5.10)

 

 Min–Max

2.68–17.3

3.46–17.3

2.68–14.9

 
  1. Concentrations are shown as the mean with the standard deviation (SD), the median and quartiles together with the minimum and maximum ranges. Data show steroid concentrations of the total participant group (n = 70). Comparison of steroid concentrations of participants with DHEA levels lower than 7 nmol/L (n = 23) and participants with DHEA levels higher than 7 nmol/L (n = 47). P-value indicates significant differences between the two groups.
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