Table 4 Constraint conditions comparison between original and optimal models over 12 months.

Constraint condition	Design point	Timestep (month)
Constraint condition	Design point	1	2	3	4	5	6	7	8	9	10	11	12
Maximum mechanical stimulus of cortical bone (J/g)	Original	0.040	0.071	0.071	0.070	0.070	0.070	0.070	0.070	0.070	0.070	0.070	0.070
Maximum mechanical stimulus of cortical bone (J/g)	Optimum	0.052	0.096	0.095	0.095	0.095	0.095	0.095	0.094	0.094	0.094	0.094	0.094
Maximum mechanical stimulus of cancellous bone (J/g)	Original	0.024	0.047	0.044	0.044	0.049	0.044	0.048	0.045	0.048	0.045	0.044	0.044
Maximum mechanical stimulus of cancellous bone (J/g)	Optimum	0.020	0.037	0.033	0.033	0.033	0.033	0.033	0.033	0.033	0.033	0.033	0.033
Maximum von Mises stress of cortical bone (MPa)	Original	32.231	30.534	30.586	29.521	29.296	29.468	29.274	29.446	29.271	29.443	29.269	29.442
Maximum von Mises stress of cortical bone (MPa)	Optimum	42.585	33.663	32.497	32.489	32.507	32.493	32.482	32.474	32.467	32.463	32.459	32.457
Maximum von Mises stress of cancellous bone (MPa)	Original	4.823	3.926	2.798	2.559	2.256	2.245	2.191	2.101	2.164	2.375	2.149	2.136
Maximum von Mises stress of cancellous bone (MPa)	Optimum	7.313	4.727	4.884	4.896	4.907	4.915	4.920	4.924	4.927	4.930	4.932	4.934

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