Figure 1

Volcano plots of correlations between sNfL concentrations and infarct/WMH volumes in (A) the overall group, and in (B) a subgroup analysis including only subject with small infarcts (< 2.5 cm3). Points in the plots indicate pairwise Spearman's rank correlations coefficients and the associated P values. Shaded areas represent P > 0.05. Δ = change from index stroke to 7-year follow-up; sNfL = serum neurofilament light chain protein; WMH = white matter hyperintensity.