Table 4 Regression analyses results for sNfL concentrations at the 7-year follow-up.

From: Circulating levels of neurofilament light chain as a biomarker of infarct and white matter hyperintensity volumes after ischemic stroke

 

Univariate models

Multivariable model 1

WMH vol. increase, per cm3

0.7 (0.5–0.9)***

0.6 (0.4–0.8)***

Age, per year

0.9 (0.7–1.2)***

0.8 (0.5–1.1)***

Male sex

1.5 (− 5.5 to 8.5)

− 0.9 (− 7.2 to 5.3)

Hypertension

9.3 (2.8 to 15.9)**

0.4 (− 5.7 to 6.5)

Hyperlipidemia

5.5 (− 2.0 to 13.1)

− 2.1 (− 9.1 to 4.9)

Diabetes mellitus

10.7 (1.3 to 20.0)*

3.8 (− 4.6 to 12.2)

Smoking

0.0 (− 6.9 to 6.9)

− 0.1 (− 6.2 to 6.0)

Subtype CE (ref)

0 (reference)

0 (reference)

 LVD

7.7 (− 7.9 to 23.3)

− 1.4 (− 15.0 to 12.2)

 CAD

− 9.0 (− 24.8 to 6.8)

− 2.3 (− 15.8 to 11.2)

 SAO

8.8 (− 5.2 to 22.9)

1.5 (− 10.6 to 13.6)

 Other determined

10.4 (− 9.9 to 30.7)

14.1 (− 3.3 to 31.5)

 Cryptogenic

0.9 (− 12.2 to 14.0)

1.4 (− 9.8 to 12.6)

 Undetermined

8.5 (− 7.9 to 24.9)

2.8 (− 11.3 to 16.9)

Estimated R2

 ≤ 21%

38%

  1. Univariate and multivariable regression models. Values are changes in sNfL [pg/ml] associated with various characteristics at the index stroke, unit increases in age, and unit increases in WMH volume during the follow-up period (i.e. β-coefficients). Within parentheses are 95% confidence intervals. Abbreviations as in Table 3.
Back to article page