Table 2 Univariable and multivariable Cox analyses for overall survival.
From: Epidemiology and prognostic nomogram for invasive breast cancer aged 85 years and older in the USA
Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) | ||||
85–89 | Reference | – | Reference | – |
90–94 | 1.65 (1.55–1.76) | < 0.001 | 1.38 (1.29–1.47) | < 0.001 |
≥ 95 | 2.83 (2.53–3.16) | < 0.001 | 2.10 (1.88–2.35) | < 0.001 |
Race | ||||
White | Reference | – | Reference | – |
Black | 1.16 (1.05–1.29) | 0.005 | 0.99 (0.89–1.10) | 0.828 |
AI/AN | 1.47 (0.87–2.48) | 0.152 | 1.68 (0.98–2.87) | 0.057 |
API | 0.87 (0.76–0.99) | 0.033 | 0.82 (0.72–0.93) | 0.003 |
Tumor size (mm) | ||||
< 20 | Reference | – | Reference | – |
20–49 | 1.73 (1.61–1.85) | < 0.001 | 1.41 (1.32–1.52) | < 0.001 |
≥ 50 | 2.64 (2.41–2.89) | < 0.001 | 1.74 (1.57–1.92) | < 0.001 |
Unknown | 3.49 (3.16–3.85) | < 0.001 | 1.53 (1.35–1.74) | < 0.001 |
Receptor subtype | ||||
HR+/HER2− | Reference | – | Reference | – |
HR+/HER2+ | 1.23 (1.10–1.37) | < 0.001 | 1.18 (1.05–1.32) | 0.004 |
HR−/HER2+ | 1.66 (1.40–1.97) | < 0.001 | 1.56 (1.31–1.85) | < 0.001 |
HR−/HER2− | 1.53 (1.39–1.69) | < 0.001 | 1.77 (1.60–1.96) | < 0.001 |
Unknown | 1.72 (1.58–1.86) | < 0.001 | 1.31 (1.20–1.43) | < 0.001 |
SEER stage | ||||
Local | Reference | – | Reference | – |
Regional | 1.74 (1.63–1.85) | < 0.001 | 1.51 (1.40–1.62) | < 0.001 |
Distant | 4.93 (4.45–5.45) | < 0.001 | 2.96 (2.63–3.32) | < 0.001 |
Unknown stage | 2.75 (2.41–3.12) | < 0.001 | 1.28 (1.10–1.50) | 0.002 |
Treatment | ||||
No treatment | Reference | – | Reference | – |
BCS | 0.38 (0.35–0.41) | < 0.001 | 0.59 (0.55–0.65) | < 0.001 |
BCS + chemo | 0.44 (0.28–0.72) | < 0.001 | 0.34 (0.21–0.56) | < 0.001 |
BCS + RTa | 0.23 (0.20–0.25) | < 0.001 | 0.35 (0.31–0.39) | < 0.001 |
Mastectomy | 0.46 (0.42–0.49) | < 0.001 | 0.55 (0.50–0.59) | < 0.001 |
Mastectomy + chemo | 0.42 (0.30–0.57) | < 0.001 | 0.33 (0.24–0.46) | < 0.001 |
Mastectomy + RTa | 0.46 (0.39–0.54) | < 0.001 | 0.42 (0.35–0.50) | < 0.001 |
RT and/or chemo | 1.12 (0.96–1.31) | 0.162 | 0.72 (0.61–0.84) | < 0.001 |
