Figure 2 | Scientific Reports

Figure 2

From: Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state

Figure 2

Dapa treatment alleviated lipids ectopic disposition and inhibited oxidative stress in skeletal muscle of mice. (A) Oil red O staining detecting lipids accumulation in skeletal muscle sections. (B) Measurement of malondialdehyde (MDA) content in serum of mice. (C) Measurement of catalase (CAT) level in serum of mice. (D) Quantitative Real-Time PCR for Superoxide Dismutase (SOD), CAT and Glutathione-peroxidase (GSH-PX) and NADPH Oxidase 4 (NOX4) in skeletal muscle. Scale bar = 200 μm. N = 3–8 per groups. *p < 0.05, **p < 0.005, ***p < 0.001, §p < 0.0001 vs NC group. #p < 0.05, ##p < 0.005, ###p < 0.001, &p < 0.0001 vs HFD group. Statistical analyses were performed using one-way ANOVA with Tukey’s multiple comparison tests. Data are represented as means ± SEM values.

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