Figure 2 | Scientific Reports

Figure 2

From: Functional evaluation of germline TP53 variants identified in Brazilian families at-risk for Li–Fraumeni syndrome

Figure 2

p53 overexpression impact in mRNA relative expression of p53’s target genes. The quantifications were normalized by endogenous housekeeping gene GUSB. The WT conditions were settled = 1 and the mRNA expression of CDKN1A (A), MDM2 (B), GADD45A (C) and PMAIP (D) genes were relativized by WT. The statistical comparisons between the variants were performed with their respective WT conditions (control or 10 Gy). p-values < 0.05 (*) were considered statistically significant; (**) p < 0.005; (***) p < 0.001; and (****) p < 0.0001. UT = untreated.

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