Table 1 Cohort characteristics.

From: Large-scale proteomics reveals precise biomarkers for detection of ovarian cancer in symptomatic women

 

Cohort

All

Benign

Ovarian cancer

I

II

III

IV

Nr. samples

Discovery

171

86

13

11

38

23

Replication

350

133

46

15

96

60

Age at Diag.a

Discovery

60.3 (14.6)

58.1 (16.6)

62.2 (11.5)

67.7 (8.7)

60.3 (12.4)

63.7 (12.4)

Replication

59.6 (13.4)

56.2 (16.1)

60.9 (11.2)

66.7 (8.4)

61.5 (10.5)

63.2 (11.6)

Age diff pvalb

 

0.41

0.19

0.84

0.90

0.93

0.83

Clin. CA-125c

Discovery

1174.2 (2382.2)

130.0 (261.1)

133.0 (175.3)

483.4 (648.2)

2032.8 (3133.3)

2389.9 (2995.0)

Replication

1049.3 (2017.8)

99.3 (157.7)

288.7 (320.3)

n.a

1636.8 (1801.3)

1981.9 (3169.2)

CA-125 diff pvalb

 

0.64

0.46

0.48

n.a

0.76

0.31

  1. aReported as mean (std.dev) age in the group. bTwo-sided Wilcoxon ranked test comparing the Discovery and Replication cohorts cClinically measured CA-125 at time of diagnosis, reported as mean (std.dev) U/ml in the group.
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