Figure 1 | Scientific Reports

Figure 1

From: Low arousal threshold is associated with altered functional connectivity of the ascending reticular activating system in patients with obstructive sleep apnea

Figure 1

Axial views of differences in voxelwise functional connectivity between the LC and the cortex or LDTg and the cortex when comparing patients with OSA-LAT vs. OSA + LAT vs. healthy controls. (A) Statistical maps of the regions where functional connectivity with the LC significantly differed among the three groups. (B) Statistical maps of the regions where connectivity with the LDTg significantly differed among the three groups (cluster-level p < 0.01, with false discovery rate correction p < 0.05). (C) The average functional connectivity value of the LC to the precuneus among controls, OSA-LAT, and OSA + LAT patients. (D) The average FC value of the LDTg to the posterior cingulate cortex among controls, OSA-LAT patients, and OSA + LAT patients. *p < 0.017, **p < 0.01, compared between two groups, post hoc Bonferroni correction. Abbreviations: OSA, obstructive sleep apnea; LAT, low arousal threshold; LC, locus coeruleus; LDTg, laterodorsal tegmental nucleus.

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