Table 3 Selected associations of SDOH with MRS CpG sites in JHS.

From: A methylation risk score for chronic kidney disease: a HyperGEN study

Trait, B(SE)

cg12116137 (PRPF8)

cg17944885 (ZNF788; ZNF20)

cg00501876 (CSRNP1)

Individual

Alcohol use

n.s

n.s

− 0.0078 (0.0025)

Physical activity

n.s

n.s

0.0034 (0.0015)

Insured

n.s

− 0.0056 (0.0028)

n.s

Depression

n.s

0.0003 (0.0001)

− 0.0004 (0.0002)

Perceived stress

-0.0012 (0.0005)

n.s

n.s

Neighborhood

Problems

n.s

0.0147 (0.0052)

n.s

SES

n.s

− 0.0007 (0.0003)

0.0008 (0.0003)

Violence

n.s

0.0203 (0.0077)

n.s

Poverty

n.s

0.0170 (0.0075)

− 0.0226 (0.0095)

AA Density

n.s

0.0195 (0.0036)

− 0.0098 (0.0045)

  1. Beta estimates presented for a CpG beta score ~ Trait. Linear mixed models were adjusted for age, sex, PC1-PC4, cell counts, and family (random). N.S.: not significant (p > 0.05).