Table 1 PheWAS of the FTO gene reveals associations with psychiatric traits related to substance use, chronotype/sleep, well-being, and neuroticism.
Trait‡ | P-valuea | Nb | Categoryc |
|---|---|---|---|
Average weekly beer plus cider intake | 3.12E-21 | 274,556 | Substance Use |
Chronotype | 7.52E-21 | 449,732 | Chronotype/sleep |
Morningness | 3.94E-18 | 345,552 | Chronotype/sleep |
Morning/evening person (chronotype) | 9.08E-18 | 345,148 | Chronotype/sleep |
Morning person (binary) | 5.11E-17 | 403,195 | Chronotype/sleep |
Sleep duration | 6.17E-14 | 384,225 | Chronotype/sleep |
Sleep duration | 6.97E-14 | 446,118 | Chronotype/sleep |
Sleep duration | 1.45E-13 | 384,317 | Chronotype/sleep |
Alcohol intake frequency | 5.15E-13 | 386,082 | Substance Use |
Ease of getting up in the morning | 2.78E-10 | 385,949 | Chronotype/sleep |
Getting up in morning | 4.15E-10 | 385,494 | Chronotype/sleep |
Snoring | 1.71E-09 | 359,916 | Chronotype/sleep |
Snoring | 2.69E-09 | 359,498 | Chronotype/sleep |
Depression—Recent poor appetite or overeating | 1.07E-08 | 126,639 | Metabolic domain |
Long sleep | 8.62E-08 | 339,926 | Chronotype/sleep |
Ever smoker | 2.61E-07 | 518,633 | Substance Use |
Drinks per day | 4.26E-07 | 537,349 | Substance Use |
Alcohol dependence | 5.15E-07 | 2322 | Substance Use |
Happiness and subjective well-being—General happiness with own health | 5.85E-07 | 126,477 | Well-being |
Drinks per week | 9.08E-07 | 414,343 | Substance Use |
10 mg response to amphetamine | 3.8017E-06 | 381 | Substance Use |
Sleep duration (mean) | 8.7287E-06 | 85,449 | Chronotype/sleep |
Irritability | 9.2669E-06 | 369,232 | Neuroticism |
Past tobacco smoking‡‡ | 2.1418E-05 | 355,594 | Substance Use |
Ever smoked‡‡ | 3.5718E-05 | 385,013 | Substance Use |
Neuroticism‡‡ | 3.958E-05 | 390,278 | Neuroticism |
