Table 4 Indirect effect of the FTO rs1421085 genotype‡ on well-being (PART wave III) through neuroticism measured in PART wave III* or wave II**

From: Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use

N

Indirect Effect (Boot 95% CI)a

Sig

N

Indirect Effect (Boot 95% CI)b

Sig

2056

−0.418 (−0.870, 0.033)*a

No

1819

−0.588 (−1.034, −0.143)*b

Yes

2062

−0.250 (−0.625, 0.133)**a

No

1779

−0.433 (−0.786, −0.079)**c

Yes

  1. Boot CI: Bootstrap Confidence Interval, Sig: Statistical significance.
  2. ‡T-allele carriers (CT or TT; coded 1) compared to CC homozygotes (CC; coded 0).
  3. *Cross-sectional mediation analysis.
  4. **Lagged longitudinal mediation analysis.
  5. aCrude model.
  6. bAdjusted for age, sex, BMI (PART wave III), AUDIT-10 (PART wave III), childhood adversities.
  7. cAdjusted for age, sex, BMI (PART wave II and III), AUDIT-10 (PART wave II and III), childhood adversities.
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