Table 5 Indirect effect of the FTO rs1421085 genotype‡ on well-being (PART wave III) through BMI measured in PART wave III* or wave II**

From: Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use

N

Indirect Effect (Boot 95% CI)

Sig

N

Indirect Effect (Boot 95% CI)

Sig

2075

0.028 (−0.004, 0.085)*a

No

1819

0.058 (0.009, 0.133)*b

Yes

2081

0.019 (−0.007, 0.067)**a

No

1767

0.031 (0.0006, 0.083)**c

Yes

  1. Boot CI: Bootstrap Confidence Interval, Sig: Statistical significance.
  2. ‡T-allele carriers (CT or TT; coded 1) compared to CC homozygotes (CC; coded 0).
  3. *Cross-sectional mediation analysis.
  4. **Lagged longitudinal mediation analysis.
  5. aCrude model.
  6. bAdjusted for age, sex, neuroticism (PART wave III), AUDIT-10 (PART wave III), childhood adversities.
  7. cAdjusted for age, sex, neuroticism (PART wave II and III), AUDIT-10 (PART wave II and III), childhood adversities.
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