Table 6 Indirect effect of the FTO rs1421085 genotype‡ on AUDIT scales (PART wave III) through neuroticism measured in PART wave III* or wave II**

From: Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use

AUDIT scale

N

Indirect Effect (Boot 95% CI)

Sig

N

Indirect Effect (Boot 95% CI)

Sig

AUDIT-10

1983

0.030 (0.001, 0.071)*a

Yes

1890

0.043 (0.009, 0.087)*b

Yes

 

1992

0.019 (−0.019, 0.060)**a

No

1853

0.001 (−0.012, 0.018)**c

No

AUDIT-C

1993

−0.003 (−0.017, 0.007)*a

No

1900

0.001 (−0.014, 0.017)*b

No

 

2002

−0.001 (−0.012, 0.006)**a

No

1863

−0.017 (−0.039, 0.0003)**c

No

AUDIT-P

2003

0.034 (0.002, 0.073)*a

Yes

1910

0.042 (0.011, 0.078)*b

Yes

 

2012

0.020 (−0.023, 0.064)**a

No

1872

0.019 (0.0006, 0.042)**c

Yes

  1. AUDIT-10: Full AUDIT scale (10 items), AUDIT-C: Alcohol consumption items, AUDIT-P: Alcohol problem items, Boot CI: Bootstrap Confidence Interval, Sig: Statistical significance.
  2. ‡T-allele carriers (CT or TT; coded 1) compared to CC homozygotes (CC; coded 0).
  3. *Cross-sectional mediation analysis.
  4. **Lagged longitudinal mediation analysis.
  5. aCrude model.
  6. bAdjusted for age, sex, BMI (PART wave III), childhood adversities.
  7. cAdjusted for age, sex, BMI (PART wave II and III), AUDIT-10 (PART wave II), childhood adversities.
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