Table 1 23 full factorial design and CPPs levels.

From: Quality by design approach of apocynin loaded clove oil based nanostructured lipid carrier as a prophylactic regimen in hemorrhagic cystitis in vitro and in vivo comprehensive study

CPPs

Units

Minimum

Maximum

Coded low

Coded high

XA

APO amount

mg

10

20

 − 1

 + 1

XB

GE amount

mg

50

100

 − 1

 + 1

XC

CH concentration

% (w/v)

0.5

1

 − 1

 + 1

  1. 1 mL of clove oil (CO) and 1% of Tween 80 were constant in all formulae.
  2. CPPs critical process parameters, APO apocynin, GE gelucire 43/01, CH chitosan.
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