Table 4 The in vitro cytotoxicity screening was computed as the 50% inhibitory concentration values (IC50) against the T24 cell line after 24 24-h incubation period.

From: Quality by design approach of apocynin loaded clove oil based nanostructured lipid carrier as a prophylactic regimen in hemorrhagic cystitis in vitro and in vivo comprehensive study

Formula

IC50 μg/mL

Pure APO

73.9 ± 2.5

Pure CO

35.7 ± 1.9*

APO/CO mix

19.2 ± 1.3*#

Plain optimal formula

12.2 ± 1.8*#$$

Optimal formula (F2)

5.8 ± 1.3*#$^

  1. Each value represents the mean ± SD (n = 3).
  2. Statistical significance is indicated as: *p < 0.05 vs pure APO, #p < 0.05 vs pure CO, $p < 0.05, $$p < 0.01 vs APO/CO mix, ^p < 0.05 vs plain optimal formula.
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