Figure 4
89Zr-CD73 IgG PET/CT and biodistribution at 4 days in CT26 and CT26/CD73 tumor mice. (A) Coronal and transaxial tomographic PET images at 4 days post-injection showing high 89Zr-CD73 IgG uptake in CT26/CD73 tumors (arrow). CD73-specific uptake was verified by low 89Zr-CD73 IgG accumulation in CT26 tumors. Target specificity was further supported by low CT26/CD73 tumor-contrast in a separate control group injected with 89Zr-isotype IgG. (B) Biodistribution data reiterated these findings by confirming greater 89Zr-CD73 IgG uptake in CT26/CD73 tumors compared to CT26 tumors. (C) Furthermore, the CT26/CD73 tumor-to-blood ratio was significantly higher for 89Zr-CD73 IgG compared to 89Zr-isotype IgG. Data are presented as the mean ± standard deviation values obtained from a single experiment (n = 5 per group).
