Figure 7
89Zr-CD73 IgG PET/CT and biodistribution at 8 days in 4T1.2 tumor mice. (A) Coronal tomographic and maximum intensity-projection (MIP) 89Zr-CD73 (left) and 89Zr-isotype IgG (middle) PET/CT in mice bearing CT26/CD73 tumors. Transaxial tomographs are shown in the right. (B) Biodistribution data of mice as above at 8 days post-injection. (C) Again, the CT26/CD73 tumor-to-blood ratio was significantly higher for 89Zr-CD73 IgG compared to 89Zr-isotype IgG. Data are presented as the mean ± standard error of obtained from two independent experiments (n = 5 per group).
