Fig. 3
From: Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
Heatmap plot showing the pattern of genetic correlation and the magnitude of narrow-sense heritability across the traits used for constructing the iLGS. Pairwise genetic correlation (\({r}_{g},\) n = 2,556) across the 72 traits (out of 87 initial traits) used in constructing iLGS was calculated using bivariate LD score regression. Positive and negative genetic correlations are shown in green and red respectively. P-values for the significance of genetic correlations are FDR corrected using the Benjamini–Hochberg method. The magnitude of the \({r}_{g}\) significance is indicated by the asterisks. The bars at the bottom of the plot show the magnitude of narrow-sense heritability across the 72 traits. The colour of each bar corresponds to the respective domain of the trait; (ALB: Albumin, ALP: Alkaline phosphatase, ALT: Alanine aminotransferase, APOA: Apolipoprotein A, APOB: Apolipoprotein B, AST: Aspartate aminotransferase, BILD: Direct bilirubin, BUN: Urea, CA: Calcium, CHOL: Cholesterol, CRE: Creatinine (in serum), CYS: Cystatin C, GGT: Gamma glutamyltransferase, GLU: Glucose, HBA1C: Glycated haemoglobin, HDL: HDL cholesterol, IGF1: Insulin growth factor-1, LDLD: LDL cholesterol, LPA: Lipoprotein A, PHOS: Phosphate, SHBG: Sex hormone binding globulin, TBIL: Total bilirubin, TES: Testosterone, TP: Total protein, TRIG: Triglycerides, UA: Urate, UCR: Creatinine in urine (enzymatic), URK: Potassium in urine, URMA: Microalbumin in urine, VITD: Vitamin D, FVC: Forced vital capacity, FEV1: Volume that has been exhaled at the end of the first second of forced expiration).
