Figure 2
Small RNA sequencing results. Volcano plot of differentially expressed (DE) miRNAs in (A) EV fraction and (B) protein fraction when UC samples were compared to controls (healthy controls and dogs with UTI). DE-miRNAs with a log2 fold change value < 0 were less abundant in UC dogs relative to healthy controls and those with a log2 fold change value > 0 were more abundant in UC dogs relative to healthy controls. (C) Principal component analysis using all DE miRNAs from EV fraction separated UC samples from HC and UTI groups. (D) Normalised read numbers of each DE miRNA in EV fractions.
