Table 2 Results of receiver operating curve analysis evaluating the diagnostic accuracy of the 3 candidate urinary EV-associated miRNAs as a diagnostic biomarker for urothelial carcinoma (UC).

From: miR-182, miR-221 and miR-222 are potential urinary extracellular vesicle biomarkers for canine urothelial carcinoma

miR candidate

AUC for UC vs. all controls

95% CI for UC vs. all controls

Sig

AUC for UC vs. UTI

95% CI for UC vs. UTI

Sig

miR-222

0.88

0.78–0.98

p < 0.001

0.86

0.72–1.00

p = 0.001

miR-221

0.79

0.66–0.92

p = 0.001

0.68

0.49–0.87

p = 0.09

miR-182

0.85

0.73–0.96

p < 0.001

0.78

0.62–0.83

p = 0.008

  1. Two control groups were used; all controls represented a population of healthy controls and dogs with diagnosed urinary tract infection (UTI), and UTI represented the group of dogs with UTIs only.
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