Table 2 Association analysis of studied genetic variants with GDM risk.
From: Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus
Genotype | Case | Control | PHWE | Pa | Crude OR (95%CI) | Pb | Adjusted OR (95%CI) | Pc |
|---|---|---|---|---|---|---|---|---|
rs17099985 | ||||||||
GG | 396 | 461 | 0.82 | 0.966 | 1 | 1 | ||
GT | 144 | 164 | 0.92(0.44–1.93) | 0.826 | 0.98(0.74–1.30) | 0.899 | ||
TT | 14 | 15 | 0.94(0.44–2.02) | 0.875 | 1.13(0.50–2.54) | 0.766 | ||
GT/TT | 158 | 179 | 1.03(0.80–1.32) | 0.833 | 0.99(0.76–1.30) | 0.963 | ||
GG/GT | 540 | 625 | 1 | 1 | ||||
TT | 14 | 15 | 0.93(0.44–1.94) | 0.837 | 1.14 (0.51–2.54) | 0.756 | ||
rs9283638 | ||||||||
CC | 234 | 286 | 0.550 | 0.011 | 1 | 1 | ||
CT | 206 | 295 | 0.85(0.67–1.09) | 0.211 | 0.87(0.67–1.13) | 0.295 | ||
TT | 73 | 58 | 1.54(1.05–2.26) | 0.029 | 1.46(0.97–2.21) | 0.071 | ||
CT/TT | 279 | 353 | 0.97(0.77–1.22) | 0.772 | 0.97(0.75–1.25) | 0.805 | ||
CC/CT | 440 | 581 | 1 | 1 | ||||
TT | 73 | 58 | 1.66(1.15–2.40) | 0.007 | 1.57(1.06–2.32) | 0.025 | ||
rs1742473 | ||||||||
TT | 395 | 475 | 0.820 | 0.350 | 1 | 1 | ||
TC | 145 | 156 | 0.59(0.26–1.35) | 0.214 | 1.14(0.86–1.52) | 0.355 | ||
CC | 14 | 10 | 0.66(0.29–1.54) | 0.341 | 2.04(0.84–4.94) | 0.113 | ||
TC/CC | 159 | 166 | 1.15(0.89–1.49) | 0.278 | 1.19(0.91–1.57) | 0.209 | ||
TT/TC | 540 | 631 | 1 | 1 | ||||
CC | 14 | 10 | 1.64(0.72–3.71) | 0.239 | 1.97(0.82–4.76) | 0.130 | ||
rs6798181 | ||||||||
TT | 411 | 468 | 0.550 | 0.590 | 1 | 1 | ||
TC | 131 | 156 | 0.96(0.73–1.25) | 0.743 | 0.98(0.74–1.39) | 0.903 | ||
CC | 10 | 17 | 0.67(0.30–1.48) | 0.321 | 0.71(0.31–1.63) | 0.423 | ||
TC/CC | 141 | 173 | 0.93(0.72–1.20) | 0.572 | 0.96(0.73–1.26) | 0.745 | ||
TT/TC | 542 | 624 | 1 | 1 | ||||
CC | 10 | 17 | 1.48(0.67–3.25) | 0.333 | 0.72(0.31–1.63) | 0.427 | ||
rs796749 | ||||||||
CC | 271 | 340 | 0.130 | 0.948 | 1 | 1 | ||
CT | 202 | 244 | 1.04(0.81–1.33) | 0.762 | 0.97(0.75–1.26) | 0.823 | ||
TT | 45 | 57 | 0.99(0.65–1.51) | 0.965 | 0.99(0.63–1.55) | 0.955 | ||
CT/TT | 247 | 301 | 1.03(0.82–1.29) | 0.806 | 0.97(0.76–1.25) | 0.832 | ||
CC/CT | 473 | 584 | 1 | 1 | ||||
TT | 45 | 57 | 0.98(0.65–1.47) | 0.902 | 1.00(0.65–1.54) | 1.000 | ||
