Table 3 Stratified analysis for associations between rs9283638 and GDM risk.
From: Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus
Variables | TT (Case/Control) | CC/CT (Case/Control) | Crude OR (95%CI) | Pa | Adjusted OR (95%CI) | Pb | Pc |
|---|---|---|---|---|---|---|---|
Age (year) | 0.017 | ||||||
≤ 30.09 | 25/45 | 202/402 | 1.11(0.66–1.86) | 0.704 | 0.99(0.58–1.71) | 0.980 | |
> 30.09 | 48/13 | 238/178 | 2.76(1.45–5.25) | 0.002 | 2.80(1.45–5.41) | 0.002 | |
Pre-BMI(Kg/m2) | 0.365 | ||||||
≤ 22.23 | 34/38 | 189/394 | 1.87(1.14–3.06) | 0.013 | 1.68(1.00–2.82) | 0.052 | |
> 22.23 | 38/20 | 251/185 | 1.40(0.79–2.49) | 0.250 | 1.35(0.75–2.45) | 0.318 | |
SBP (mmHg) | 0.757 | ||||||
≤ 110.08 | 38/40 | 205/331 | 1.53(0.95–2.47) | 0.079 | 1.66(1.00–2.74) | 0.050 | |
> 110.08 | 35/18 | 235/249 | 2.06(1.14–3.74) | 0.017 | 1.55(0.82–2.93) | 0.182 | |
DBP (mmHg) | 0.570 | ||||||
≤ 69.53 | 41/37 | 206/304 | 1.64(1.01–2.64) | 0.044 | 1.75(1.06–2.91) | 0.030 | |
> 69.53 | 32/21 | 234/276 | 1.80(1.01–3.20) | 0.047 | 1.29(0.69–2.40) | 0.431 | |
FPG (mmol/L) | 0.115 | ||||||
≤ 4.79 | 25/50 | 176/513 | 1.46(0.88–2.43) | 0.148 | 1.54(0.90–2.63) | 0.118 | |
> 4.79 | 48/8 | 264/67 | 1.52(0.69–3.37) | 0.300 | 1.33(0.58–3.03) | 0.500 | |
1hPG (mmol/L) | 0.714 | ||||||
≤ 8.26 | 19/46 | 104/460 | 1.83(1.03–3.25) | 0.040 | 1.69(0.93–3.07) | 0.085 | |
> 8.26 | 54/12 | 336/120 | 1.61(0.83–3.11) | 0.158 | 1.60(0.81–3.15) | 0.173 | |
2hPG (mmol/L) | 0.205 | ||||||
≤ 7.11 | 18/50 | 129/478 | 1.33(0.75–2.37) | 0.324 | 1.31(0.72–2.39) | 0.375 | |
> 7.11 | 55/8 | 311/102 | 2.26(1.04–4.89) | 0.040 | 2.15(0.97–4.75) | 0.059 | |
HbA1C (%) | 0.588 | ||||||
≤ 5.20 | 23/40 | 159/435 | 1.57(0.91–2.71) | 0.103 | 1.53(0.87–2.68) | 0.138 | |
> 5.20 | 50/18 | 281/145 | 1.43(0.81–2.55) | 0.220 | 1.43(0.78–2.61) | 0.251 | |
TG (mmol/L) | 0.485 | ||||||
≤ 2.54 | 42/30 | 222/371 | 2.34(1.42–3.85) | 0.001 | 2.20(1.29–3.75) | 0.004 | |
> 2.54 | 31/28 | 218/209 | 1.06(0.62–1.83) | 0.830 | 1.04(0.58–1.85) | 0.894 | |
