Figure 1
From: Central neurodegeneration in Kennedy’s disease accompanies peripheral motor dysfunction
Diffusivity of corticospinal tracts were assessed between cortical grey/white matter boundary to the level of the inferior boundary of the lateral ventricles, at which point corticospinal tracts demonstrated marked intra-voxel overlap. Axonal degeneration was observed within juxtacortical white-matter of corticospinal tracts (premotor; motor; somatosensory) in ALS and SBMA patients, relative to healthy control participants. Representative 3D reconstruction of delineated tracts from a healthy control participant is shown in native space. SBMA patients demonstrated widespread increase in axial diffusivity across all reconstructed corticospinal tracts across left and right hemispheres. ALS patients demonstrated a selective increase in axial diffusivity specific to corticospinal streamlines seeded from the primary motor and somatosensory cortices. Mean and standard deviation. *Indicates significance at p < 0.05; **indicates significance at p < 0.01; Bonferroni corrected.
